Advanced Imaging of Glenohumeral Instability: It May Be Less Complicated than It Seems

Pharmacological PKA inhibition: all may not be what it seems.

Signaling through the cyclic adenosine monophosphate-dependent protein kinase [protein kinase A (PKA)] is an important and widely studied area of signal transduction research. This signaling pathway is commonly investigated through the use of the pharmacological PKA inhibitors H89 and KT 5720. Both of these compounds are thought to block PKA actions through competitive inhibition of the adenosi...

Pharmacological PKA Inhibition : All May Not Be What It Seems

Page 1 Overview of cAMP Signaling The transduction of extracellular signals to intracellular responses is one of the most important and complicated aspects of cellular life. The cyclic adenosine monophosphate (cAMP) signaling pathway is involved in numerous processes and is widely regarded as the “classical” second messenger signaling pathway. cAMP is synthesized from adenosine triphosphate (AT...

"Elevator Music": More Than It Seems

"The musically aware hostess no longer allows the butler, or her husband, to sling records on to the turntable in a haphazard way. She no longer risks the dangers of the soup being spilled by Haydn's 'Surprise' Symphony, or Mrs. Alias-Jones choking over the fish because an ill-timed bit of jazz trumpet has frightened her. She now supplies a ready-made background of elegant and suitable music to...

Light curing may not be as simple as it seems – again!

Using Critiquing for Improving Medical Protocols: Harder than It Seems

Medical protocols are widely recognised to provide clinicians with high-quality and up-to-date recommendations. A critical condition for this is of course that the protocols themselves are of high quality. In this paper we investigate the use of critiquing for improving the quality of medical protocols. We constructed a detailed formal model of the jaundice protocol of the American Association ...